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Additionally, stress-inducing agents such as tunicamycin, thapsigargin and histidinol have been shown to modulate CHAC1 regulation, indicating its involvement not only during ER stress but also in the context of the ISR ( CHAC1 promoter is the primary mechanism for the transcriptional upregulation of the gene
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Des preuves rcentes montrent que les sujets diagnostiqus avec un trouble du spectre autistique (TSA) ont des niveaux significativement plus faibles de glutathion que les enfants en dveloppement typique
Regarding the role of redox regulation, we previously reported a positive association between central levels of GSH in the prefrontal cortex measured by magnetic resonance spectroscopy, and structural and functional connectivity along the cingulum bundle in healthy young adults, suggesting that redox regulation supported by the GSH-redox cycle may be involved in white matter maturation [42]
