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Adverse reactions after a B12 injection may include: A feeling of tightness in the chest Anaphylaxis (difficulty breathing or swallowing) Chest pain Congestive heart failure Heart palpitations Pulmonary edema Rapid heartbeat (tachycardia) Shortness of breath Vascular thrombosis Musculoskeletal Effects Your musculoskeletal system makes up your bones, tendons, cartilage, and connective tissues