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Graphical Abstract Similar content being viewed by others Introduction Epilepsy is one of the most common neurological disorders that affects about 13% of the population

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For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135

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