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With the progression of ALS there may be an additional decrease in GABA concentration due to a decrease in glutamine released from the glutamate/glutamine neurotransmitter cycle being required for net GABA synthesis (Figure 1C shows the additional decrease in cellular GABA predicted with further progression of ALS

Further research investigating time-course changes in citrulline concentration following CM supplementation is required to determine the optimal strategy, although the best recommendation at the moment would be 1 h prior to exercise

Serious adverse events are rare and comparable to other widely used medications

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