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So far, studies on these new, multi-agonist drugs suggest that activating multiple receptors may lead to greater weight loss than GLP-1 alone

Jacobs, L., Hoehne, M

Glucose metabolism in cancer: the Warburg effect and beyond

Unlike selective GLP-1 receptor agonists, GLP2s unique dual-action mechanism activates both incretin pathways simultaneously, representing a novel therapeutic class often referred to as twincretins. The peptides strategic design includes lipidation with a C20 fatty diacid moiety attached via a hydrophilic linker, which enables albumin binding and extends its half-life to approximately 5 days, permitting convenient once-weekly dosing