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The liver then converts the GH signal to IGF-1 over 8 to 24 hours, but that conversion is blunted in proportion to hepatocellular mass loss, as documented in cirrhosis research published in the Journal of Clinical Endocrinology and Metabolism

The effects of growth hormone on adipose tissue: old observations, new mechanisms, Kopchick JJ, Berryman DE, Puri V, Lee KY, Jorgensen JOL, Nature Reviews Endocrinology (2020, Vol