Multiple nonhormonal medications have shown benefits for treating hot flashes, including: anti-depressant medications, such as: selective serotonin reuptake inhibitors (SSRIs), such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft) selective norepinephrine reuptake inhibitors (SNRI), such as venlafaxine (Effexor XR) gabapentin (Neurontin), an antiseizure drug thats also used to treat epilepsy, migraine, and nerve pain clonidine (Kapvay), an antihypertensive drug thats used to lower high blood pressure In some cases, your doctor may prescribe sleeping medication to help you sleep through hot flashes
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