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After RSL3 treatment, the viability of A549 and HT1080 cells was significantly reduced by the combination of DHODH deletion and LDHB silencing compared to both single alterations and could be completely rescued by FER1 supplementation (Fig

FASEB J 21:22262236 Kato S, Ishita S, Suguwara K, Mawatari K (1993) Cystine/glutamate antiporter expression in retinal Mller glial cells: implications for DL-alpha-aminoadipate toxicity

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The development of tumor treatment strategies targeting GSH-degrading enzymes faces challenges, including different roles of these enzymes in different types of tumor and their impact on the immune response or tumor microenvironment