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For instance, overexpression of prostacyclin synthase or inhibition of miRNA-34a has been demonstrated to shift macrophage populations towards an M2 phenotype, reducing inflammation and enhancing tissue repair in experimental models of ALD.34 41 These findings highlight the therapeutic potential of targeting macrophage polarisation to balance pro-inflammatory and anti-inflammatory responses, offering a strategy to mitigate the liver damage caused by chronic alcohol consumption

Animal Lifespan Does Not Equal Human Healthspan A lifespan difference in a selected mouse strain can arise from effects on one common cause of death without improving broader health

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