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One meta-analysis involving patients with T2D without cardiovascular disease found a reduction in MACE associated with SGLT2i regimens of (adjusted pooled OR and 95% CI) 0.82 (0.730.92), with GLP1-RAs regimens of 0.93 (0.811.06), and with combined therapy of 0.70 (0.500.98)

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Any illicit drug today can contain fentanyl or other potent synthetics