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GSSG, oxidized glutathione

Klyosov, A

The nature of the spherical vesicles observed near MVBs in plant cells Although we identified a plant-specific vesicle population that appears to originate from MVBs, is labeled by retromer and VSR proteins, and whose formation depends on retromer components, additional evidence is required to demonstrate that these vesicles traffic to the TGN and function as bona fide retrieval carriers

Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition