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Taken together, these pooled safety analyses (119123) and CV outcome safety trials (124127), together with review of published data from numerous clinical trials ( Conclusions Once known primarily as a marker of activated T-cells and associated with immune regulation, signal transduction, and apoptosis, it is now more generally recognized that the actions of DPP-4 may be more widespread, and that it has the potential, either directly or indirectly, to influence metabolic processes
10.1016/j.celrep.2016.06.062 Cell Rep
Response: We thank the commenter for underscoring the importance of the time from Decision to Transfer (order) to the ED departure, one of the numerator components for the measure
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