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Biotinylated proteins were further purified using cation-exchange chromatography to remove the BirA, followed by SEC

Endocrinology 2010;151:569-75.ArticlePubMed 56

As leses pigmentadas orais na Doena de Addison so causada pela produo aumentada do hormnio adrenocorticotrpico (ACTH) e do hormnio estimulante de melancitos (-MSH), em resposta produo reduzida do cortisol pela glndula adrenal