Pay in 4 interest-free payments of $5.61 Learn more
Ships within 48 hours · Estimated delivery Jul 31 - Aug 5
Selective NNMT inhibitor substrate site-targeting mechanism with IC50 of 1.2 M in reference assay conditions Selectivity over related methyltransferases does not significantly affect other enzymes in the NAD salvage pathway at research concentrations Reduces intracellular 1-methylnicotinamide (1-MNA) formation in cell-based assay models Studied in adipocyte, liver, and skeletal muscle cell-based research models examining NNMT-dependent methylation pathway dynamics Referenced at Sigma-Aldrich (SML2832) and in peer-reviewed literature on NNMT enzyme biology Membrane-permeable quaternary quinolinium scaffold studied for intracellular NNMT target engagement in cell-based models Batch and lot identifiers on all labeling for full laboratory documentation compliance Research Background 5-Amino-1MQ was first characterized as a selective NNMT inhibitor in published research literature in 2018
Sterchi JM, Muss HB, Weidner N
R.DillonM
These arrhythmias and impaired LV function were significantly inhibited by co-administration of 4-ClDzp (64M): arrhythmia scores with diamide + 4-ClDzp were 0.4 0.2 (n=5
US$ 25.65
US$ 23.56
US$ 26.87
US$ 25.44
US$ 22.59
US$ 28.58
US$ 29.56
