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The lack of comparable reports in the published literature, along with the infrequent occurrence of these specific symptoms during clinical trials, highlights the importance of postmarketing surveillance

This limits the affordability of many patients, especially from low- and middle-income groups and those who do not have medical insurance, restricting market growth

Additionally, compounded semaglutide has been marketed without requiring a prescription from a healthcare provider

Chronic neuroinflammationmediated by activated microglia and astrocytesexacerbates neuronal injury through the release of pro-inflammatory cytokines such as TNF- and IL-1 (Singh et al., 2019)