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performed a cross-trial analysis using data from clinical trials of GLP-1RAs (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER-6 [59], and AMPLITUDE-O), SGLT2is (CANVAS and CREDENCE), and finerenone (FIDELIO-DKD and FIGARO-DKD) to estimate the effects of the triple combination therapy of GLP-1RA, SGLT2i, and finerenone using the actuarial method [60]

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Standardization of methodologies across studies will also be essential to improve reproducibility and comparability

Confirmation of identity and verification of purity for each component lot are essential, since an under-dosed, degraded or copper-depleted preparation will distort results