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Particularly, in ubiquitination-mediated antimicrobial selective autophagy (also named as xenophagy) 11 , the host immune system can utilize specific E3 ligases to mark intracellular invading pathogens with ubiquitin molecules, which are subsequently recognized by ubiquitin-binding autophagy receptors, such as Optineurin, p62, and NDP52 12,13,14,15,16,17 , thereby guiding the pathogens for autophagic degradation to prevent infection spread 18,19,20