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PIONEER 3 study design 1,4 In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 1864 adult patients with type 2 diabetes on metformin alone or metformin with a sulfonylurea were randomized to RYBELSUS 3 mg (n=466), RYBELSUS 7 mg (n=465), RYBELSUS 14 mg (n=465), or Januvia 100 mg (n=467), all once daily

Its usually the result of multiple small disruptions over the time

DOI 10.1111/bph.13274

"To maintain vaginal health while using GLP-1 agonists, I recommend staying well-hydrated, using a vaginal probiotic and considering the use of vaginal moisturizers if experiencing dryness," Bone said