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Another strategy focuses on identifying and targeting specific metabolic dependencies, a concept referred to as metabolic vulnerability therapy. In cell subpopulations with elevated OXPHOS activity and glutamine-driven TCA cycle flux, the combined use of glutamine metabolism inhibitors such as CB-839 with oxidative stress inducers, including doxorubicin or isothiocyanates, markedly increases intracellular ROS levels
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Varicose veins develop when venous valves fail and vein walls lose elasticity due to collagen degradation, chronic inflammation, and impaired endothelial function
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