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However, certain populations are at higher risk of deficiency: Adults over 50 (reduced absorption capacity) Individuals following vegan or strict vegetarian diets Those with gastrointestinal conditions such as Crohns disease or celiac disease Individuals taking long-term acid-reducing medications (PPIs, H blockers) When oral supplementation is insufficient or absorption is compromised, vitamin B12 shots deliver the nutrient directly into the bloodstream, bypassing the digestive system entirely

However, unless -cell failure occurs simultaneously, insulin resistance will not lead to T2DM

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Some doctors and specialists may also consider lower BMI thresholds when patients have weight-related conditions, reflecting evidence that Asian populations tend to develop obesity-related metabolic complications including Type 2 diabetes and cardiovascular disease at lower BMI levels than Western populations