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This engineered live bacteria can activate the intestinal FXR-fibroblast growth factor 15/19 signaling pathway, alleviate vancomycin-induced bile acid accumulation and liver fibrosis

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Metopimazine is a dopamine D2 receptor antagonist that exerts its antiemetic effects via the chemoreceptor trigger zone, which mediates nausea and vomiting through peripheral receptors

Written informed consent was obtained from all participants after providing them with a complete description of the study