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Administration of WSLE NE markedly improves behavioral outcomes and histopathological features compared to WSLE alone by enhancing antioxidant enzyme activity, suppressing pro-inflammatory cytokines, and downregulating neurotoxicity-associated gene expression (110)

The rationale is that effects accumulate during the course and persist between courses, with new courses reinforcing the previous effects

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In darker or more pigmented skin types, changes such as darker or grey skin may be observed instead of redness, highlighting the importance of recognizing diverse presentations of TSW