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The 2024 Cureus systematic review by Jaiswal and Jawade reaches the same conclusions across more than 60 cited studies: the wound-healing cascade and the delivery enhancement are two separable mechanisms, and which one dominates depends on needle depth, needle architecture, and how the serum is introduced [1]

Reduces Stress & Anxiety: Research indicates that the delta-sleep-inducing peptide may act as a therapeutic agent by modulating the stress response through its effects on the hypothalamic-pituitary-adrenal (HPA) axis and stress hormones

GLP-1RA use was also associated with lower risk for two important clinical endpoints relevant to AF: ischemic stroke and cardiovascular mortality, compared with DPP4i, but no difference compared with SGLT2i

however, across conditions, clinical benefits are mixed and context-dependent