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However, in the Diabetes Prevention Programme, which randomised 3,234 individuals with IGT to intensive lifestyle modification, metformin or placebo, there was no difference in the incidence of cardiovascular events between the treatment groups over 3 years [48]

[13] [14] The SUSTAIN-6 trial also demonstrated a reduction in major adverse cardiovascular events in patients with type 2 diabetes at high cardiovascular risk, though this is not a specific licensed indication in the UK

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"Document dates of participation in any nutrition and physical activity program or membership." Finley filed an appeal on Feb