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Hadem J, Tacke F, Bruns T, Langgartner J, Strnad P, Denk GU, et al

Simultaneously, they significantly influence immune cell function, thereby creating an immunosuppressive environment that further enhances drug resistance ( Furthermore, immune cells in the tumor microenvironment can potentially influence drug metabolism and elimination by releasing specific cytokines and chemical substances, thereby exacerbating drug resistance mechanisms ( Cancer stem cells (CSCs) are a population of tumor cells with self-renewal and differentiation potential

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