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Metformin, initially utilized for the treatment of diabetes, has been discovered to have great cardiovascular benefits as well (Long et al., 2022

Brown A, McArdle P, Taplin J, Unwin D, Unwin J, Deakin T, et al

To further validate, our in vivo and in vitro datasets of elevated cytokines in presence of ADA, we analyzed transcriptomic data of RA PBMCs with significantly higher ADA and RA synovial macrophages with significantly lower expression of ADA