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There are two primary types of melanin: Eumelanin: This is responsible for dark colors, such as black and brown

Surface charge-based application in which mainly the positive surface charge of PNPs will be utilized to produce an adsorption-mediated transcytosis Utilization of surfactants like Tween 80 (T80) and poloxamer as a coating agent, which could be coated or linked to PNP surfaces to target the BBB Surface modification of PNPs using PEG to provide long-circulating characteristics and BBB-crossing ability to PNPs Ligand conjugation with specific proteins, antibodies, peptides, etc., on PNP surfaces to enhance brain targeting via effective movement across the BBB crossing Utilization of magnetic field for driving NPs to the BBB target site For TfRs and glioma cells, which are upregulated transporters and receptors, the substrates or ligands have been conjugated to NP surfaces so that they can specifically bind to the overexpressed targets of diseased cells and trigger them via endocytosis, which is described in Figure 3 ( FIGURE 3 Various PNPs developed for targeting therapeutics to the brain for the treatment of neurological disorders like PD, AD, psychotic disorders, brain tumors, and stroke will be further discussed in this review, and the molecular and functional effects obtained in the preclinical model will be outlined

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