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J Hepatol 65:579588 Tveden-Nyborg P, Birck MM, Ipsen DH, Thiessen T, Feldmann LB, Lindblad MM, Jensen HE, Lykkesfeldt J (2016) Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs

All of these mechanisms are regulated by cytokines, either by directly attracting and activating cells that produce extracellular matrix or indirectly by regulating pulmonary inflammation, redox balance, and the activity of various enzymatic systems, such as matrix metalloproteinases (MMP) and their inhibiting and clotting enzymes [63]

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However, annual follow-up is advisable to monitor changes in morphology or colour over time