fda semaglutide ruling Federal judge upholds FDA's removal of Ozempic, Wegovy from drug shortage list Compound versions of GLP-1 drugs

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The Overlap Risk: Why Concurrent Use Is Not Recommended The Pharmaceutical Journal (Royal Pharmaceutical Society, December 2025) states that concurrent administration of tirzepatide and semaglutide "could heighten side effects" due to their "overlapping incretin activity." When both drugs are active simultaneously, the GLP-1 receptor faces amplified agonist load