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Expert Opin Drug Discov 18(10):11171132

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Additionally, the opioid excess theory posits that incomplete digestion of gluten can produce peptides with opioid-like activity, which can cross the blood-brain barrier and affect neurotransmission, potentially leading to the exacerbation of autistic symptoms[96]

Thus, across both exchange strategies, peptide-exchanged HLA-C*05:01 complexes were indistinguishable from wild-type HLA-C*05:01 in their capacity to engage KIR2DL1 and completely inhibit NKG2D/DNAM-1driven NK-cell activation