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However, patients diagnosed with Mast Cell Activation Syndrome (MCAS) or severe histamine intolerance must carefully navigate what functional medicine practitioners call the 'histamine paradox.' While NAC is a widely recognized mast cell stabilizer that effectively reduces ROS-triggered degranulation, it is also fundamentally a sulfur-containing amino acid derivative

Instead, it may influence the production of pheomelanin (a lighter pigment) over eumelanin (a darker pigment) in new skin cells