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In patients without diabetes, tirzepatide provided an additional 3.6% weight loss compared to semaglutide, while in patients with diabetes, the percentage change in body weight was not statistically different between the two groups

3.2.2.1 Curcumin Curcumin, the bioactive compound extracted from turmeric , shows the potent therapeutic effects in various diseases including renal IRI, shock and myocardial ischemia with its antioxidant properties ( via the activation of Nrf2, Sirtuin-1 and Sirtuin-3 ( via inhibiting Keap1, upregulating Nrf2 and inducing the nuclear translocation of Nrf2 ( via Sirtuin-1-Nrf2-ARE signaling pathway ( via Nrf2 to ameliorate mitochondrial oxidative stress, and further restore the activities of renal mitochondrial respiratory enzyme in various kidney diseases ( 3.2.2.2 Resveratrol Besides promoting mitochondrial biogenesis, resveratrol also attenuates mitochondrial dysfunction and restores renal function via other multiple mechanisms