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This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

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Patients with bad living habits such as smoking and excessive alcohol consumption, those suffering from diseases such as hypertension and diabetes, as well as those who are obese (with a BMI 28) were excluded from this study

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𝐌𝐢𝐜𝐫𝐨𝐧𝐞𝐞𝐝𝐥𝐢𝐧𝐠 𝐰𝐢𝐭𝐡 𝐠𝐥𝐮𝐭𝐚𝐭𝐡𝐢𝐨𝐧𝐞 , 𝐓𝐡𝐢𝐬 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐜𝐨𝐦𝐛𝐢𝐧𝐞𝐬 𝐭𝐡𝐞 𝐬𝐤𝐢𝐧-𝐫𝐞𝐬𝐮𝐫𝐟𝐚𝐜𝐢𝐧𝐠 𝐛𝐞𝐧𝐞𝐟𝐢𝐭𝐬 𝐨𝐟 𝐦𝐢𝐜𝐫𝐨𝐧𝐞𝐞𝐝𝐥𝐢𝐧𝐠 𝐰𝐢𝐭𝐡 𝐭𝐡𝐞 𝐚𝐧𝐭𝐢𝐨𝐱𝐢𝐝𝐚𝐧𝐭 𝐚𝐧𝐝 𝐬𝐤𝐢𝐧-𝐛𝐫𝐢𝐠𝐡𝐭𝐞𝐧𝐢𝐧𝐠 𝐩𝐫𝐨𝐩𝐞𝐫𝐭𝐢𝐞𝐬 𝐨𝐟 𝐠𝐥𝐮𝐭𝐚𝐭𝐡𝐢𝐨𝐧𝐞. 𝐓𝐡𝐢𝐬 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐢𝐬 𝐮𝐬𝐞𝐝 𝐟𝐨𝐫

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