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doi:10.1007/s00125-010-1937-z Lauffer L, Grieco A, Iakoubov R, Brubaker PL (2009) Metformin activates the AMPK pathway and improves survival of murine and human L-cells but does not directly increase GLP-1 secretion

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It is well-known that several treatment-related characteristics, including mode, timing, frequency of administration and complexity of the treatment, play a role in patients' preference and compliance